Actin filaments in cholesterol-treated neurons, replated to Lee et al., PNAS (2020).
Axons can be insulted by traumatic injury, toxins or neurodegenerative disorders. Injured axons become degenerated, often leading to devastating neurological conditions such as cognitive disorders and paraplegia. To restore the function, axons need to re-extend to the original target. We aim to understand the mechanisms underlying axon regeneration, to identify novel components regulating axon regeneration and ultimately to develop methods to improve nerve repair after neural damage.